Finite Element Modeling of Atherosclerotic Plaque Formation and Evolution | |
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( Volume 2 Issue 4,April 2016 ) OPEN ACCESS | |
Author(s): | |
I.V. Kirillova, E.L. Kossovich, M.S. Shevtsova, R.A. Safonov, N.O. Chelnokova, A.A. Golyadkina | |
Abstract: | |
The appearance of lipid plaques on the walls of blood vessels is called atherosclerosis. According to the World Health Organization’s statistics, atherosclerosis can affect blood vessels, regardless of age and occupation of the person. In spite of a number of studies, devoted to the investigation of this disease, the exact factors and their influence on atherosclerotic plaque formation and evolution have not yet been determined. Presented investigation examines the influence of mechanical factors on the evolution of atherosclerosis. In this paper a time-dependent coupled problem of the atherosclerotic plaque formation and evolution in the coronary artery has been presented. Penetration of low-density lipoproteins (LDL) into internal layers of the blood vessel, diffusion of macrophages and deformation of the vessel wall with endothelial defects have been considered. The mathematical model of the arterial wall has been implemented using the finite element (FE) package Comsol Multiphysics. The solution has been obtained by means of the following working modes: Convection/Diffusion (for the LDL penetration process), Diffusion (for the LDL modified by macrophages, or foam cells), and Moving Mesh (for visualizing the wall deformation). |
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